The Protective Effect of SRI 63-441 on Ischemic Liver Injury Using the Isolated Perfused Rat Liver: Combined Protocol With Superoxide Dismutase.
نویسندگان
چکیده
PREVENTION or reduction of ischemia/ reperfusion injury would be of great benefit in organ transplantation. Here we briefly report preliminary studies evaluating a combined protocol using SRI 63-441 (Sandoz Pharmaceuticals. Raritan. NJ), a potent platelet-activating factor receptor antagonist. 1 and superoxide dismutase (SOD), an oxygen free radical.scavenger, in an attempt to reduce ischemic injury to the liver.
منابع مشابه
Pharmacologic modulation of experimental postischemic hepatic function.
The present study evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 minutes of warm ischemia. After warm ischemia, livers were harvested and underwent 90 minutes of warm, oxygenated, sanguinous perfusion on an isolat...
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عنوان ژورنال:
- Transplantation proceedings
دوره 20 1, suppl 1 شماره
صفحات -
تاریخ انتشار 1988